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Breakthrough in Cancer Drug Delivery: Polymer-Based Nanocarriers Show Promise Against Aggressive Tumors

Researchers have made a promising breakthrough in the fight against two of the most aggressive and treatment-resistant cancers: glioblastoma (GBM) and triple-negative breast cancer (TNBC). The study, conducted in collaboration with Polymer Factory, explored new ways to deliver cancer drugs more effectively using advanced polymer-based nanocarriers.


Treating GBM and TNBC is notoriously difficult. Traditional chemotherapy struggles with issues such as poor drug solubility, toxicity, and, in the case of brain tumors, the blood–brain barrier – a natural defense that blocks many drugs from reaching the tumor.

To tackle these challenges, the research team tested two innovative drug delivery systems:

  • Polymeric micelles made from two commercially available systems

  • Dendritic nanogels (DNGs) based on Polymer Factory’s proprietary bis-MPA dendritic nanotechnology

These nanocarriers were designed to encapsulate and transport common chemotherapy agents like docetaxel, carboplatin, and doxorubicin, increasing their stability and effectiveness. The results were encouraging: - DNGs were especially effective at delivering water-soluble drugs, offering high loading capacity. - Micelles improved solubility and uptake of water-insoluble drugs like docetaxel.

- Both systems showed strong tumor penetration and significantly reduced cancer cell growth inlaboratory tests.

“This study represents a meaningful step forward in precision oncology,” said Mats Wallnér, CEO of Polymer Factory. “By improving how cancer drugs are delivered, we can potentially make treatments both safer and more effective for patients with hard-to-treat tumors.” The findings not only offer hope for future cancer therapies but also highlight the potential of polymer-based nanotechnology in personalized medicine.


This disclosure contains information that Polymer Factory is obliged to make public pursuant to the EU Market Abuse Regulation (EU nr 596/2014). The information was submitted for publication, through the agency of the contact person, on 08-08-2025 08:55 CET.


For more information, please contact:

Mats Wallnér, acting CEO

Phone: +46 (0) 70 951 95 06

 

About Polymer Factory

Polymer Factory was founded in 2006 at KTH Royal Institute of Technology and its Board of Directors have been essential in driving dendritic nanotechnology research to commercialization for almost 15 years – expertise that has been transferred to the Company’s products. Emerging from many years of cutting-edge research within the field, Polymer Factory today has, in the Company’s assessment, the world’s largest product portfolio of dendritic materials with customers ranging from Big Pharma, MedTech and BioTech companies, to research-intensive institutes and academic research groups. Polymer Factory has also used the Company’s vast knowledge and expertise to develop a patented calibration technology, named SpheriCal®, designed for Mass Spectrometry instruments.

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