Dendritic amine-NHS coupling
Procedure for the coupling of amine-reactive N-hydroxysuccinimide (NHS) activated carboxylic acids to our dendritic scaffolds.
Thiol-ene click functionalization of thiol dendrons
Procedure for the coupling of alkenes to our thiol-functional dendrons via UV-initiated thiol-ene "click."
EDC coupling of amines to dendritic COOH
Procedure for the coupling of amine-containing substrates to our carboxylic acid functional dendritic scaffolds.
(Note: An analogous procedure can be used to functionalize amine function dendritic scaffolds with carboxylic acid-containing substrates)
Deprotection of NHBoc
Procedure for the facile deprotection of NHBoc functional scaffolds, quantitatively revealing primary amine groups for further modification.
CuAAC“Click” coupling of dendritic alkynes/azides
Procedure for the coupling of dendritic alkenes and azides through the efficient and mild "click" chemistry approach.