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Read publications related to Polymer Factory's technology, and learn more about the science behind our innovations. 

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Bis-MPA Materials in Nanotechnology (Coatings)

“Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches using Visible Light Initiated Thiol-ene Coupling Chemistry”. Viktor Granskog, Oliver C. J. Andren, Yanling Cai, Marcela Gonzalez-Granillo, Li Fellander-Tsai, Hans von Holst, Lars-Arne Haldosen, Michael Malkoch. Malkoch. Adv. Funct. Mater., 25: 6596–6605.

“Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research..” Carlmark A, Malmström E, Malkoch M. PubMed; 2013 42(13):5858-79;

“Templating gold surfaces with function: a self-assembled dendritic monolayer methodology based on monodisperse polyester scaffolds..” Oberg K, Ropponen J, Kelly J, Löwenhielm P, Berglin M, Malkoch M. PubMed; 2012 29(1):456-65;

“Bifunctional Dendronized Cellulose Surfaces as Biosensors.” AMaria I. Montañez, Yvonne Hed, Simon Utsel, Jarmo Ropponen, Eva Malmström, Lars Wågberg, Anders Hult and Michael Malkoch. Biomacromolecules; 2011; 12; 2114-2125.

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“Self-Assembled Arrays of Dendrimer-Gold-Nanoparticle Hybrids for Functional Cell Studies.” Anders Lundgren, Yvonne Hed, Kim Oeberg, Anders Sellborn, Helen Fink, Peter Löwenhielm, Jonathan Kelly, Michael Malkoch, Mattias Berglin. Angewandte Chemie, International Edition; 2011; 50(15); 3450-3453.

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“Role of Architecture and Molecular Weight in the Formation of Tailor-Made Ultrathin Multilayers Using Dendritic Macromolecules and Click Chemistry.” Robert Vestberg, Michael Malkoch, Matthew Kade, Peng Wu, Valery V. Fokin, K. Barry Sharpless, Eric Drocenmuller, Craig J. Hawker. J. Polym. Sci., Part A: Polym. Chem.; 2007; 45(14); 2835–2846.

“Dendritic Structures Based on Bis(hydroxymethyl)propionic Acid as Platforms for Surface Reactions”.  Emma Östmark, Lubica Macakova, Tommaso Auletta, Michael Malkoch, Eva Malmström, Eva Blomberg. Langmuir; 2005; 21; 4512-4519.

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Bis-MPA Materials in Medicine

“Dendritic Polyester Scaffolds: Functional and Biocompatible Precision Polymers for drug delivery application”. Sandra Garcia-Gallego, Michael Malkoch. Polymeric Drug Delivery Techniques. Translating Polymer Science for Drug Delivery, Aldrich Material Science

“Multivalent, Bifunctional Dendrimers Prepared by Click chemistry”. Peng Wu, Michael Malkoch, Jasmine Hunt, Robert Vestberg, Eiton Kaltgard, M. G .Finn, Valery V. Fokin, K. .B Sharpless, Craig J. Hawker. Chem. Commun.; 2005; (46); 5775-5777.

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“Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers”. Feliu N, Walter MV, Montañez MI, Kunzmann A, Hult A, Nyström A, Malkoch M, Fadeel B.; 2012 Mar ; 33(7):1970-81

“Designing Dendrimers for Biological Applications”. Cameron C. Lee, John A MacKay, Jean M J Frechet, Francis C Szoka. Nature Biotechnology, 2005 Nature Publishing Group.

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“A Single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas”. Cameron C. Lee, Elizabeth R. Gillies, Megan E. Fox, Steven J. Guillaudeu, Jean M. J. Fre´chet, Edward E. Dy, Francis C. Szoka. PNAS November 7, 2006 vol. 103 no. 45 16653.

“Traceable nanoparticles with drugs – the future of cancer weapons”. Christian Porsch, Yuning Zhang, Åsa Ostlund, Peter Damberg Cosimo Ducani, Eva Malmström, and Andreas M. Nystrom. 19F-based Polymer Nanoparticles as Breast Cancer Theranostics Particle & Particle Systems Characterization, online first 28 February 2013, DOI: 10.1002/ppsc.201300018

"Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery”. Patrik Stenström, Dario Manzanares, Yuning Zhang, Valentin Ceña and Michael Malkoch. Molecules, 2018, 23(8), 2028.

Bis-MPA Materials in Photonic Applications

“Europium confined cyclen dendrimers with photophysically active triazoles”. Per Antoni, Michael Malkoch, George Vamvounis, Daniel Nyström, Andreas Nyström, Mikael Lindgren and Anders Hult, J. Mater. Chem. 2008.

“Thiophene-Cored bis-MPA dendrimers for optical power limiting applications”. R. Vestberg, C. Nilsson, C. Lopes, P. Lind, B. Eliasson, E. Malmström. J. Pol. Sci., Part A, Polym Chem Ed., 2005, 43, 1177.

Bis-MPA Materials in Catalysis

“Dendritic Oxazoline Ligands in Enantioselective Palladium-Catalyzed Allylic Alkylations”. Michael Malkoch, Kristina Hallman, Sergej Lutsenko, Anders Hult, Eva Malmström, Christina Moberg. J. Org. Chem.; 2002; 67; 8197–8202.

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Dendrimers and Click Chemistry

“Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes”.Wu P, Feldman AK, Nugent AK, Hawker CJ, Scheel A, Voit B, Pyun J, Frechet JMJ, Sharpless KB and Fokin VV. Angewandte Int. Ed., 2004, 43, 30, 3928-3932.

“Multivalent, bifunctional dendrimers prepared by click chemistry”.Wu P, Malkoch M, Hunt JN, Vestberg R, Kaltgad E, Finn MG, Fokin W, Sharpless KB and Hawker CJ. Chem. Comm., 2005, 46, 5775-5777.

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“Structually diverse dendritic libraries; A highly efficient functionalization approach using Click chemistry”.Malkoch M, Schleicher K, Drockenmuller E, Hawker CJ, Russel TP, Wu P. and Fokin VV. Macromolecules, 2005, 38, 9, 3663-3678.

“A chemoselective approach for the accelerated synthesis of well-defined dendritic architectures”.Antoni P, Nyström D, Hawker CJ, Hult A and Malkoch M. Chem Comm., 2007, 22, 2249-2251.

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“New methodologies in the construction of dendritic materials”.Carlmark A, Hawker CJ, Hult A and Malkoch M. Chemical Society Reviews, 2009, 38, 352-362.

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“Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications”.Antoni P, Hed Y, Nordberg A, Nyström N, von Holst H, Hult A and Malkoch M. Angewandte Int. Ed., 2009, 48, 2126-2130.

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“Accelerated Growth of Dendrimers via Thiol-Ene and Esterification Reactions”. Montanez MI, Campos LM, Antoni P, Hed Y, Walter MV, Krull BT, Khan A, Hult A, Hawker CJ and Malkoch M. Macromolecules, 2010.

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Dendritic Mass Spectrometry Calibrants

“Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant”. Scott M. Grayson, Brittany K. Myers, Jonas Bengtsson, Michael Malkoch. J. American Society for Mass Spectrometry; 2014; 3; 303-309.

“The identification of synthetic homopolymer end groups and verification of their transformations using MALDI-TOF mass spectroscopy”.Yeija Li, Jessica N. Hoskins, Subramanya G. Sreerama, Michael A. Grayson and Scott M. Grayson. J. Mass Spectroscopy, 2010, 45, 587-611.

“MALDI-TOF Mass Spectral Characterization of Polymers Containing an Azide Group: Evidence of Metastable Ions”.Yeija Li, Jessica N. Hoskins, Subramanya G. Sreerama and Scott Grayson. Macromolecules, 2010.

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“SpheriCal®‐ESI: A dendrimer‐based nine‐point calibration solution ranging from m/z 273 to 1716 for electrospray ionization mass spectrometry peptide analysis”.Joakim Romson, Jamie Godfrey, Michael Malkoch, Scott M. Grayon, Åsa Emmer et al. Rapid Communications is Mass Spectrometry, 2021.


Dendrimers in Hydrogels

“High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder”.Qigang Wang, Justin L. Mynar, Masaru Yoshida, Eunji Lee, Myongsoo Lee, Kou Okuro, Kazushi Kinbara & Takuzo Aida (2010), 339-343.

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Hyperbranched Polymers

“Hyperbranched copolymer micelles as delivery vehicles of doxorubicin in breast cancer cells”. Xianghui Zeng, Yuning Zhang, Zhihua Wu, Pontus Lundberg, Michael Malkoch and Andreas M. Nyström, Journal of Polymer Science, Volume 50, Issue 2, pages 280–288, 15 January 2012.

“Utility of the hyperbranched polymer Hybrane S1200 for production of instant-release particles by hot melt extrusion”. Raviña-Eirín E, Gómez-Amoza JL, Martínez-Pacheco R., Drug Dev Ind Pharm. 2013 Jul;39(7):1107-12.

Bis-MPA Materials Synthesis & Functionalization

“Fluoride-Promoted Esterification (FPE) Chemistry: A Robust Route to Bis-MPA Dendrons and Their Postfunctionalization” Patrik Stenström, Oliver C. J. Andren, Michael Malkoch. Molecules 2016, 21(3), 366; doi:10.3390/molecules21030366

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