Dendritic Hydrogel Coating To Overcome Surgical Site Infection

Display antibacterial effect toward all strains tested: S. aureus, P. aeruginosa, E. coli, and E. faecalis, methicillin-resistant, S. aureus (MRSA), S. epidermidis and P. acnes

Nosocomial infections are infections that develop as a result of medical or surgical care and affect approximately 5% of hospitalized patients. Out of all nosocomial infection, 70% of the infections are caused by antibiotic-resistant pathogens. Surgical-site infections (SSI) account for more than 30% of nosocomial infections, which represents a major risk for nearly 42 million patients who undergo surgery each year.

The current treatment protocol to prevent SSI often involves a single dose of antibiotic prophylaxis prior to the incision with additional doses of lengthy procedures. This works through targeting internal components of bacterias however, this has also led to the development of several multidrug-resistant (MDR) bacterial strains.

A non-toxic hydrolytically fast-degradable antibacterial hydrogel with a two-component system that forms antibacterial hydrogels within 1 min is herein presented to treat SSI.

It consists of:

  1. an amine functional linear-dendritic hybrid based on linear poly(ethylene glycol) and dendritic 2,2-bis(hydroxymethyl)propionic acid (bis-MPA), and

  2. a di-N-hydroxysuccinimide functional poly(ethylene glycol) cross-linker

The antibacterial hydrogel can be used during the first crucial 24 h period without relying on conventional antibiotics hence overcoming the development of MDR.

The antibacterial property of the hydrogen has been tested and demonstrated in both in vivo and in vitro settings. The hydrogel can be applied in an in vivo mouse model setting using a two-component syringe delivery system with a tuneable range to fat tissue and cartilage (G′= 0.5–8 kPa). A list of common bacteria such as S. aureus, P. aeruginosa, E. coli, and E. faecalis, methicillin-resistant, S. aureus (MRSA), S. epidermidis and P. acnes strains were tested in vitro.

This new approach and method of quick cross-linking antibacterial polymer networks made using a dual syringe application could potentially be used to proactively treat SSI in a surgical setting without incurring a risk in developing multidrug-resistant (MDR) bacterial strains.

For in-depth information please refer to the research paper below: >>>Antibiotic-Free Cationic Dendritic Hydrogels as Surgical Site Infection Inhibiting Coatings

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