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Formation of Ultrathin Multilayers Films Using Click Chemistry and Dendritic Macromolecules

Layer-by-layer synthesis of dendritic thin films on silicon wafers


Click Chemistry Using Azide and Alkyne Derivatives

Click Chemistry has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical science. It is often used in bioconjugation, nanoparticle surface modification and pharmaceutical-related polymer chemistry.

The Cu(I) catalyzed ‘‘Click’’ reaction of multi-functional terminal azide and alkyne derivatives has been proved to allow formation of well-defined, covalent layer-by-layer films in which the structure of these films can be accurately defined.


The azide and alkyne-terminated dendrimers based on bis-MPA technology allows the accurate control of the growth of the thin film due the available size/generation of dendrimer that can be selected from. As comparing with linear analogues, the three-dimensional dendritic architecture of alkyne and azide dendrimers revealed to provide more regular and defect-free growth of dendritic thin films.


Polymer Factory supplies multiple generations of Bis-MPA “Clickable” Dendritic materials with end groups such as azide, acetylene which are excellent click chemistry reagents with a wide variety of applications.


For detailed synthetic strategy please refer to:

“Role of Architecture and Molecular Weight in the Formation of Tailor-Made Ultrathin Multilayers Using Dendritic Macromolecules and Click Chemistry.”

Robert Vestberg, Michael Malkoch, Matthew Kade, Peng Wu, Valery V. Fokin, K. Barry Sharpless, Eric Drocenmuller, Craig J. Hawker. J. Polym. Sci., Part A: Polym. Chem.; 2007; 45(14); 2835–2846.


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