As recently published in Biomacromolecules, researchers CQM at Universidade de Madeira report their evaluation of generation 4 and 5 bis-MPA dendrimers as drug delivery vehicles for anti-cancer drug doxorubicin (DOX), as well as the cytotoxicity of the dendrimers toward healthy human cell lines.
The authors report that both hydroxyl and partially amine functionalized dendrimers were cytocompatible, with the dendrimers not affecting the cell viability of lines tested independent of the chemical groups present at the surface.
Moreover, the molecules could be efficiently loaded with DOX, with the partially amine functionalized dendrimers displaying higher loading capacity and fast release of the payload, while the hydroxyl dendrimers were able to release the drug in a more sustained manner. The researchers emphasize that through control of the dendrimer generation and surface functionality, the drug loading and release capacity could be modulated.
The DOX-loaded dendrimers were evaluated against a range of cancer cell lines and human stem cells, confirming that the bis-MPA dendrimers were able to transport DOX to the interior of cancer cells and exert cytotoxic effects.
Read the full paper here.
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