Tested on human lung carcinoma A549
A Family of heterofunctional bis-MPA dendrimers (HFDs) with internal disulfide bridges were synthesized and exploited as macromolecular templates that selectively rupture into distinctly different and highly reactive thiol functional monomers with dual functionality. When present in physiological environment with enzymatic systems, such as GSH-Grx and Trx present in all living cells, selective rupturing of the dendrimers will be initiated in the presence of these external stimuli.
The performance of the PEGylated HFDs was conducted in the presence of human lung carcinoma A549 cells and give rise to promising results detailed a short rupturing time period at relevant concentrations. The thiol functional monomers released led to an increase in the reactive oxidative species (ROS) level locally around cancerous tissue. ROS has the ability to suppress and induce targeted cell death in the tumor hence is believed to decrease cancer propagation and effectively halting cancer growth.
It is also worth mentioning that this is the first report that detailed a bis-MPA dendrimer family with rupturing dual capacity suited for both materials sciences and nanomedicine.
For in-depth information please refer to the research paper below:
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