Product Description:
Polymer Factory's bis-MPA NHBoc-azide dendrons are monodisperse, multifunctional scaffolds with 1 protected amine focal point and an exact number of azide surface groups. After deprotection, the amine focal point can be used for EDC coupling to carboxyl substrates or coupling to NHS-esters, forming stable amide bonds under mild conditions suitable to biological substrates.
 
The azide surface groups can be used for click chemistry coupling with alkyne-functional substrates via CuAAC or SPAAC, with click reactions typically proceeding rapidly at room temperature and  compatible with many biological substrates. Organic azides are also commonly used in conjugation strategies involving Staudinger ligation. The bis-MPA polyester scaffolds are biodegrable and have low cytotoxicity, making them ideal candidates for use in biological research applications.
 
Common applications include as multi-functional linkers for bioconjugation and signal enhancement in fluorescent labelling.
 
Reacts with:
Carboxyl/COOH via amidation (e.g. EDC, NHS)
Alkynes via CuAAC/SPAAC click chemistry
 
Related Publications
 
Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers - Biomaterials, 2012, 33 (7), 1970-1981                             
Multivalent, bifunctional dendrimers prepared by click chemistry - Chem. Comm., 2005, 0, 5775-5777                         
Structurally Diverse Dendritic Libraries:  A Highly Efficient Functionalization Approach Using Click Chemistry -  Macromolecules, 2005, 38 (9), 3663-3678                                
Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research - Chem. Soc. Rev., 2013, 42, 5858-5879                                     
Synthesis and in Vitro Evaluation of Monodisperse Amino-Functional Polyester Dendrimers with Rapid Degradability and Antibacterial Properties - Biomacromolecules, 2017, 18 (12), 4323-4330                       
Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery - Molecules, 2018, 23 (8), 2028