Product Description:
Polymer Factory's bis-MPA carboxyl-NHBoc dendrons are monodisperse, multifunctional scaffolds with 1 carboxylic acid focal point and an exact number of protected amine surface groups. After deprotection, the amine surface groups can be used for EDC coupling to carboxyl containing substrates or coupling to NHS esters to form stable amide bonds with carboxyl functional substrates.
 
The carboxyl focal point can be used for further coupling to amine containing materials by well known amide bond forming chemistry commonly used in bioconjugation, such as EDC/NHS.  The bis-MPA polyester scaffolds are biodegrable and have low cytotoxicity, making them ideal candidates for use in biological research applications.
 
Typical uses of carboxylic acid functional dendrons often target bioconjugation to lysine residues in proteins and antibodies to give conjugates with stable amide bonds. Applications include development of Antibody Drug Conjugates and fluorescent labelling of proteins/antibodies.
 
Reacts with:
Carboxyl/COOH via amidation (e.g. EDC, NHS)
Amines/lysine via amidation (e.g. EDC, NHS)
 
Related Publications
 
Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers - Biomaterials, 2012, 33 (7), 1970-1981                                                                           
Synthesis and in Vitro Evaluation of Monodisperse Amino-Functional Polyester Dendrimers with Rapid Degradability and Antibacterial Properties - Biomacromolecules, 2017, 18 (12), 4323-4330                                           
Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research - Chem. Soc. Rev., 2013, 42, 5858-5879                                                                              
Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery -  Molecules, 2018, 23 (8), 2028