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Product Description:

Polymer Factory's BowtieD® bis-MPA dendrimers are monodisperse, bifunctional scaffolds with an exact number of boc-protected amine and azide groups at the periphery. After deprotection, the amine surface groups can be used for EDC/DCC coupling or coupling to NHS esters, while the azide groups can be used for further functionalization via highly efficient click chemistry (e.g. CuAAC, SPAAC) to furnish a bifunctional molecules with two modes of activity. Our bis-MPA polyester scaffolds are biodegrable and have low cytotoxicity, making them ideal candidates for use in biological research applications.

 

Related Publications :

  1. Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers - Biomaterials, 2012, 33 (7), 1970-1981
  2. Multivalent, bifunctional dendrimers prepared by click chemistry - Chem. Comm., 2005, 0, 5775-5777
  3. Structurally Diverse Dendritic Libraries:  A Highly Efficient Functionalization Approach Using Click ChemistryMacromolecules, 2005, 38 (9), 3663-3678
  4. Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery - Molecules, 2018, 23 (8), 2028
  5. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomasPNAS, 2006, 103 (45), 16649-16654
  6. Biological Evaluation of Polyester Dendrimer:  Poly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and ArchitectureMol. Pharm., 2005, 2 (2), 129–138

BowtieD® Bifunctional Bis-MPA Dendrimer, Generation 1, 2 NHBoc, 2 Azide

SKU: PFBTD-[G1/G1]-S-[NHBoc/Azide]
PriceFrom €437.00
    • Type: BowtieD® Dendrimer
    • Core: Sulfide
    • Product Code : PFBTD-[G1/G1]-S-[NHBoc/Azide]
    • End Group Functionality 1: NHBoc
    • End Group Functionality 2: Azide
    • Generation: 1
    • Number of Surface Groups: 2 + 2
    • Molecular weight: 989.15 g/mol
    • bis-MPA = 2,2-bis(hydroxymethyl)propionic acid
    • Form: Colourless oil
    • Purity: >95%
    • Delivery Time: Available on request
    • MSDS
    • CoA Cover Sheet
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