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Technology highlight: Dendrons as Multifunctional Bioconjugation Linkers

Polymer Factory produces a wide range of dendrons, many of which are particularly valuable in applications where scientists seek to conjugate substrates to biological molecules such as antibodies and proteins. These include antibody labelling, development of antibody drug conjugates (ADCs) and drug delivery.

Bioconjugation is typically performed using a bifunctional linker, which is often a short linear polymer or peptide, with a reactive handle for coupling to biomolecule at one end and the chosen substrate at the other. As such, these linkers attach one substrate per conjugation site.

Dendrons offer a unique advantage of presenting one group reactive with the biomolecule along with increasing number of sites for attachment of multiple substrates. Polymer Factory’s dendron technology is also modular, allowing adjustment of the structures to best fit customer needs. For example, custom molecules can be produced to include a specific bioconjugation group (e.g. NHS-ester, azide, malemide), while also offering either 2, 4 or 8 handles to attach multiple copies of the substrate. It is also possible to add or tune a spacer at the interior of the molecule, in order to tailor solubility or release of the payload.

This technology can be used to increase the payload of ADCs, enhance the signal of fluorescently labelled antibodies and tailor solubility of biologically active molecules.

If you are interested in finding out more about our dendritic products, or would like to discuss design of unique dendritic linkers, contact us at


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