Improved drug efficacy towards drug-resistant breast cancer cell (Resi-MCF-7)
A family of amphiphilic linear-dendritic polymer hybrids - hydrophobic cholesterol compartments as chain-terminus groups of the dendritic block and hydrophilic bifunctional linear poly(ethylene glycol) (PEG) block - forms nanocarriers (NCs) through effective self-assembly.
The modular nature of the NCs enables the encapsulation of single or dual anticancer drugs. The dual drug delivery system aims to lower the effective drug concentration against drug-resistant cancer such as resistant breast cancer cells, Resi-MCF-7. It was shown that the dual drug delivery of both doxorubicin (DOX) and triptolide enhanced the therapeutic efficacy with a 63% significant increase against Resi-MCF-7 as compared to free DOX. The drug delivery efficacy was also strengthened by the ability of NCs to escape from lysosomal encapsulation, allowing them to effectively relocate the drug to mitochondria as well as nuclei.
The study demonstrated that the use of linear dendritic NCs could be a new approach to overcome the drug detoxification mechanism in Resi-MCF-7. The absolute structural control present in this family of linear-dendritic polymeric NCs offers a promising approach to build a reproducible drug delivery system that can be further enhanced and improved.
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