Polymer Factory’s dendrimers, dendrons and BowtieD® bifunctional dendrimers are a series of monodisperse, defect-free macromolecules produced by a series of well controlled chemical reactions. Using our expertise in dendrimer synthesis, we are able to design and produce these materials to have exact numbers of reactive handles, for simple modification using efficient and straightforward chemical reactions. Read on to find out the unique properties of these materials.
Dendrimers - precision nanomaterials
Our dendrimers are grown outward in a layer-by-layer fashion, with each layer termed a “generation.” As the structure increases in size with the addition of each generation, molecular weight and number of functional end groups increase exponentially.
Since we have a high level of control over the synthesis, each generation contains exact numbers of end groups, with a wide range available as stock products, for example:
PFD-010205 Bis-MPA Carboxyl Dendrimer, Generation 2 has exactly 12 carboxylic acid groups at the periphery.
PFD-010308 Bis-MPA Azide Dendrimer, Generation 2 has exactly 24 azide groups at the periphery.
PFD-010412 Bis-MPA Ammonium Dendrimer, Generation 4 has exactly 48 primary amine groups at the periphery.
The large and exact numbers of functional end groups allows attachment of many active moieties with a high degree of control. The dendrimers act as ideal scaffolds for amplification of interactions with biomolecules and amplification of signal in diagnostic applications, and are shown to act as drug delivery vectors for hydrophobic drugs.
Dendrons - multifunctional bioconjugation linkers
Unlike the symmetric, globular structures of dendrimers, dendrons contain a single chemical reactive group at the core and an exact number of orthogonal reactive groups at the periphery. Their bifunctional nature makes them ideal as multifunctional bioconjugation linkers to biomolecules. Each generation of dendron will have one group at the focal point and an increasing number of reactive groups at the surface:
PFDO-011113 bis-MPA NHBoc Dendron, Thiol Core, Generation 1 has 1 thiol at the core and 2 boc-protected amine groups at the periphery.
PFDO-021805 bis-MPA Carboxyl Dendron, Biotin Core, Generation 2 has 1 biotin at the core, and 4 carboxylic acid groups at the periphery.
PFDO-031713 bis-MPA NHBoc Dendron, NHS Core, Generation 3 has 1 NHS-ester at the core, and 8 boc-protected primary amine groups at the periphery.
PFDO-040412 bis-MPA Ammonium Dendron, Acetylene Core, Generation 4 has 1 alkyne at the core, and 16 primary amine groups at the periphery.
Our dendrons are ideal scaffolds for use as multifunctional linkers in antibody conjugation, ADCs, diagnostics and more. The dendrons are available with functional groups for efficient bioconjugation, including Click Chemistry, NHS-amidation, Thiol-maleimide and biotinylation.
BowtieD® Bifunctional Dendrimers
Polymer Factory’s latest product offering is bifunctional dendrimers. These molecules essentially combine two functional dendrons in the same structure, presenting multiple copies of two different functional groups at the periphery, with exact numbers of each. For example:
PFBTD-011310101 BowtieD® Bifunctional Bis-MPA Dendrimer, Generation 1, 2 NHBoc, 2 Hydroxyl has exactly 2 boc-protected amines at one end, and exactly 2 hydroxyl groups at the other.
PFBTD-021310208 BowtieD® Bifunctional Bis-MPA Dendrimer, Generation 2, 4 NHBoc, 4 Azide has exactly 4 boc-protected amines at one end, and exactly 4 azide groups at the other.
PFBTD-031310304 BowtieD® Bifunctional Bis-MPA Dendrimer, Generation 3, 8 NHBoc, 8 Acetylene has exactly 8 boc-protected amines at one end, and exactly 8 alkyne groups at the other.
BowtieD® dendrimers are our most sophisticated product line and are inherently customizable by varying the generation or end groups of either dendron. They are perfect candidates for many-to-many conjugation and are designed to allow orthogonal modification.
Functional groups
We aim to offer a wide range of structures that are easy to use and allow customers to efficiently modify with biological moieties, bioactive groups, APIs, fluorescent tags and more. As such, our stock products are equipped with functional groups for Click Chemistry, maleimide conjugation, Staudinger ligation, amidation and other common bioconjugation strategies. In addition, dendrons are supplied with biotin and fluorescent tags for diagnostic applications, or PEG chains for enhancement of solubility. You can see our full range of compatible functional groups below.
If you would like to know more, reach out to us at info@polymerfactory.com