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Dendritic Hydrogel Coating To Overcome Surgical Site Infection
Display antibacterial effect toward all strains tested: S. aureus, P. aeruginosa, E. coli, and E. faecalis, methicillin-resistant, S. aureus (MRSA), S. epidermidis and P. acnes Nosocomial infections are infections that develop as a result of medical or surgical care and affect approximately 5% of hospitalized patients. Out of all nosocomial infection, 70% of the infections are caused by antibiotic-resistant pathogens. Surgical-site infections (SSI) account for more than 30% o
Bis-MPA Dendrons as Versatile Fluorescent Amplifiers for Enhanced Biomolecule Labeling
Bis-MPA dendritic scaffolds with orthogonal features provide enhance fluorescent and chemoselective labeling of biomolecules such as the Human IgG Fc antibodies Cost-efficient fluorescent dyes with versatile multicolor labeling properties have become a powerful tool for bioimaging and diagnostic. While widely employed, its inherently low sensitivity is deemed as a major drawback. To overcome this, there is a need to identify dyes with strong fluorescence signals and offers ac
Bis-MPA Dendron with Ammonium Functionalities Offers Effective Penetration in P.aeruginosa Biofilms
Penetration and Accumulation of Dendrons with Different Peripheral Composition in Pseudomonas Aeruginosa Biofilms
Sulfur-containing Bis-MPA Dendrimers as Prodrugs for Intracellular Delivery of ROS to Fight Cancer
From therapeutic drug carrier to being prodrugs for intracellular delivery of ROS to fight against cancer
Dual Drug Delivery System Using Linear-dendritic Polymeric Nano-carriers
Dual drug delivery system using linear dendritic polymeric nanocarriers to enhance therapeutic efficacy towards drug-resistant cancer cells.
A Comparison of Material Stability and Biocompatibility of Bis-MPA Dendrimers and PAMAM Dendrimers
An in vitro biocompatibility evaluation study of stability and biocompatibility of Bis-MPA dendrimer
Biotin - The Ideal Molecule for Protein and Macromolecules Labelling
Biotin-avidin interaction is commonly exploited to detect and purity proteins The high affinity between biotin and avidin is unaffected by extreme pH, high temperature, organic solvents and other denaturing agents. These features of biotin and avidin are useful for purifying or detecting proteins conjugated to either components. Besides favourable biotin-avidin interaction, the newly released biotin dendrons are offered with both carboxylic acid and protected-amine periphery
Structurally Perfect High-generation Dendrimers
A publication by the Department of Chemistry and Chemical Biology, McMaster University, Canada highlighted the difficulties in synthesizing high-generation dendrimer and provided an alternative convergent synthesis approach. The publication highlighted the synthetic diversity, including SPAAC click chemistry, to efficiently prepare structurally perfect high-generation bis-MPA dendrimers with varying cores and peripheral functionalities. Not only that, it also signaled the pot